Gene information
Official symbol C3
Official full name complement C3
Gene type protein-coding gene
Chromosome19p13.3
Alias symbolCPAMD1; ARMD9; C3a; C3b
Gene familyReceptor ligands; C3 and PZP like, alpha-2-macroglobulin domain containing; Complement system activation components
Resources
Entrez Gene 718
HGNC HGNC:1318
Ensembl ENSG00000125730
Vega OTTHUMG00000150335
UCSC uc002mfm.4
GO terms: 103 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001906 cell killing GO Biological Processes -7.45870005 11 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002253 activation of immune response GO Biological Processes -3.86084748 14 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002455 humoral immune response mediated by circulating immunoglobulin GO Biological Processes -5.71650362 10 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002673 regulation of acute inflammatory response GO Biological Processes -15.6954767 14 More
GO:0002675 positive regulation of acute inflammatory response GO Biological Processes -10.8573789 13 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002886 regulation of myeloid leukocyte mediated immunity GO Biological Processes -10.0272645 11 More
GO:0002920 regulation of humoral immune response GO Biological Processes -5.73581155 7 More
GO:0002922 positive regulation of humoral immune response GO Biological Processes -6.27426612 6 More
GO:0003002 regionalization GO Biological Processes -7.48750854 38 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005766 primary lysosome GO Cellular Components -4.39854337 10 More
GO:0005775 vacuolar lumen GO Cellular Components -10.7475427 18 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006956 complement activation GO Biological Processes -7.12107226 12 More
GO:0006958 complement activation, classical pathway GO Biological Processes -5.86439052 10 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0008277 regulation of G protein-coupled receptor signaling pathway GO Biological Processes -5.69311965 11 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010827 regulation of glucose transmembrane transport GO Biological Processes -18.4601079 28 More
GO:0010828 positive regulation of glucose transmembrane transport GO Biological Processes -9.82015489 15 More
GO:0010883 regulation of lipid storage GO Biological Processes -22.5241589 19 More
GO:0010884 positive regulation of lipid storage GO Biological Processes -7.64826410 7 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0016064 immunoglobulin mediated immune response GO Biological Processes -6.28897630 13 More
GO:0016322 neuron remodeling GO Biological Processes -3.23941104 3 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019724 B cell mediated immunity GO Biological Processes -7.00231964 14 More
GO:0021700 developmental maturation GO Biological Processes -12.5205714 23 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0030449 regulation of complement activation GO Biological Processes -3.83961894 4 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035578 azurophil granule lumen GO Cellular Components -4.57928114 8 More
GO:0042551 neuron maturation GO Biological Processes -3.82142288 8 More
GO:0042582 azurophil granule GO Cellular Components -4.39854337 10 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045807 positive regulation of endocytosis GO Biological Processes -11.0143833 14 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0048259 regulation of receptor-mediated endocytosis GO Biological Processes -11.3903749 15 More
GO:0048260 positive regulation of receptor-mediated endocytosis GO Biological Processes -10.1090317 11 More
GO:0048469 cell maturation GO Biological Processes -5.75704415 12 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048880 sensory system development GO Biological Processes -3.47450215 31 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050764 regulation of phagocytosis GO Biological Processes -16.0793009 29 More
GO:0050766 positive regulation of phagocytosis GO Biological Processes -13.5971167 15 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0071695 anatomical structure maturation GO Biological Processes -11.1692541 20 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0090207 regulation of triglyceride metabolic process GO Biological Processes -7.43834818 8 More
GO:0098883 synapse pruning GO Biological Processes -6.79133706 5 More
GO:0150062 complement-mediated synapse pruning GO Biological Processes -5.05559485 3 More
GO:0150063 visual system development GO Biological Processes -3.59465978 31 More
GO:0150064 vertebrate eye-specific patterning GO Biological Processes -5.65340552 3 More
GO:0150146 cell junction disassembly GO Biological Processes -6.56194591 5 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling GO Biological Processes -7.80587066 38 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905954 positive regulation of lipid localization GO Biological Processes -22.7388039 24 More
KEGG pathways: 11 records
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05150 Staphylococcus aureus infection KEGG Pathway -9.38905356 13 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05322 Systemic lupus erythematosus KEGG Pathway -4.88971598 10 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
clozapine PharmGKB 26503818 view
compstatin DTC 25494040 view
pegcetacoplan TTD view
Related studies: 10 records
Molecular factor Omics type Application Objective MI type Reference
NM_000064.4:c.364C>G genomics myocardial infarction[diagnosis] myocardial infarction Csaszar A et al. Exp Clin Immunogenet. 2001
NM_000064.4:c.364C>G genomics myocardial infarction[diagnosis] myocardial infarction Leban N et al. Diagn Pathol. 2013
complement C3 proteomics old myocardial infarction[diagnosis] old myocardial infarction Muscari A et al. Cardiology. 1995
complement C3 proteomics myocardial infarction[diagnosis] myocardial infarction Renko J et al. Scand J Clin Lab Invest. 2004
complement C3 proteomics good predictor myocardial infarction[diagnosis] myocardial infarction Carter AM et al. Atherosclerosis. 2009
complement C3 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Akhtar N et al. Heart Asia. 2012
complement C3 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Muscari A et al. Am J Med. 1995
complement C3 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Muscari A et al. Am J Med. 1995
complement C3 proteomics atorvastatin plus vitamin E[treatment (pharmacotherapy)] myocardial infarction Muscari A et al. Cardiovasc Drugs Ther. 2001
complement C3 proteomics statin[treatment (pharmacotherapy)] acute myocardial infarction Al-Kuraishy HM et al. J Lab Physicians. 2017
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